GABA receptor (Y-aminobutyric acid)

GABA – A (ionic receptor)

GABA – B (metabolic receptor)

GABA – C (ionic receptor)

GABA is an important neurotransmitter in the central nervous system and works by binding to its receptors.

GABA-A receptors, widely distributed throughout the nervous system, mainly in the postsynaptic membrane, with the highest cerebellar content, subbranch of the hippocampus. Through its activation, it causes CL ion cell influx, which hyperpolarizes or depolarizes neurons.

GABA - B receptors, present in the postsynaptic parts of some excitatory and inhibitory neurons, the highest cerebellum, at the cerebral cortex level, activate cation channels (Ca ions, K ions) through GABA

GABA, the C receptor, is also coupled to Cl ion channels.

* GABA-A receptor and GABA-C receptor can form ligand-gated Cl ion channels, GABA-B receptors belong to the G protein-coupled receptor family, and accompanied by Ca ions, K ion channels, of which GABA-A receptors are the main inhibitory receptors in the central nervous system, barbiturates and benzodiazepines can act on GABA-A receptors, exerting their sedative, hypnotic, anticonvulsant effects.

The presynaptic membrane release transmitter is triggered by the influx of Ca ions

Transmitters are released in the form of vesicles in the mode of action of exocytosis

IPSP is a local potential, not an action potential

IPSP is due to changes in postsynaptic membrane ion channel permeability, independent of the anterior membrane